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Efficacy and Safety of minimally invasive corneal cross linking: KeraVio study

Efficacy and Safety of minimally invasive corneal cross linking: KeraVio study - KeraVio study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000031829
Enrollment
40
Registered
2018-03-25
Start date
2018-03-21
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconus and other corneal ectasia

Interventions

Violet light glass Riboflavin drops

Sponsors

Minamiaoyama Eye Clinic
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: We defined the progression of corneal ectasia over the preceding 12 months as the following criteria. 1. an increase of at least 1.00 diopter (D) in the steepest keratometry 2. an increase of at least 1.00 D in the manifest refraction and manifest refractive spherical equivalent - a degradation 3. an decrease of at least 0.1 mm in base curve of hard contact lens

Exclusion criteria

Exclusion criteria: 1. Thinnest corneal thickness < 300 micron 2. Present medication of Psoralen 3. History of photodermatosis 4. History of epilepsy 5. History of fluorescein induced allergy 6. Cases with possibly undergoing keratoplasty during the observation period 7. Cases considered as inappropriate by physicians 8. Cases offering the stop of the treatment

Design outcomes

Primary

MeasureTime frame
1. Kmax, thinnest corneal thickness 2. Axial length 3. Best corrected visual acuity 4. Uncorrected visual acuity 5. Manifest refractive spherical equivalent 6. Manifest cylinder refraction

Countries

Japan

Contacts

Public ContactHidenaga Kobashi

Minamiaoyama Eye Clinic Department of Ophthalmology

himon@hotmail.co.jp03-5772-1451

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026