Clinical study of continuous intraoperative vagus nerve stimulation for monitoring function of recurrent laryngeal nerve during esophagectomy for esophageal cancer

Clinical study of continuous intraoperative vagus nerve stimulation for monitoring function of recurrent laryngeal nerve during esophagectomy for esophageal cancer - Monitoring RLN function during esophageal cancer surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000031819

Enrollment

150

Registered

2018-03-20

Start date

2017-12-27

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal cancer

Interventions

An EMG endotracheal tube is used. The nerve function is continuously monitored using NIM-Response 3.0 with APS equipped on the vagus nerve electrode once an operation.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients esophageal caner who plan for the elective surgeries. 2) Patients with signed informed consent.

Exclusion criteria

Exclusion criteria: 1) Patients with impaired judgement.

Design outcomes

Primary

Measure	Time frame
vocal cord movement	—

Secondary

Measure	Time frame
hoarseness, aspiration, pneumonia	—

Countries

Japan

Contacts

Public ContactSoji Ozawa

Tokai University School of Medicine Department of Gastroenterological Surgery

tokai.eso@tokai-u.jp0463-93-1121

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026