Effectiveness of natural S-equol supplement for premenstrual symptoms: a randomized, double-blind, placebo-controlled trial

Effectiveness of natural S-equol supplement for premenstrual symptoms: a randomized, double-blind, placebo-controlled trial - Effectiveness of equol for PMS (ESPRESSO study)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000031815

Enrollment

124

Registered

2018-04-01

Start date

2018-07-31

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PMS

Interventions

Natural S-equol supplement placebo

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: With moderate to severe PMS or PMDD Equol non-producer Without severe complications

Exclusion criteria

Exclusion criteria: Hypersensitive to soy foods

Design outcomes

Primary

Measure	Time frame
Premenstrual symptoms	—

Countries

Japan

Contacts

Public ContactTakashi Takeda

Kindai University Center for Traditional Asian Medicine

take@med.kindai.ac.jp072-366-0221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026