A retrospective study on beta cell function in type 2 diabetic patients using GLP-1 receptor agonist

A retrospective study on beta cell function in type 2 diabetic patients using GLP-1 receptor agonist - A retrospective study on beta cell function in type 2 diabetic patients using GLP-1 receptor agonist

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000031697

Enrollment

Registered

2018-03-25

Start date

2018-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ( a ) Beta cell function was assessed with Glucagon challenge test ( GCT ) which is using 1mg intravenous glucagon injection. ( b ) DPP4is or liraglutide was administrated for 5years. ( c ) 5 years after administration of DPP-is or liraglutide, beta cell function was re-assessed using GCT.

Exclusion criteria

Exclusion criteria: type 1 diabetes, an estimated glomerular filtration rate (eGFR) < 30ml/min, liver cirrhosis, steroid or any hyperglycemic drugs use and malignant desease

Design outcomes

Primary

Measure	Time frame
Serum CPR level with glucagon challenge test	—

Secondary

Measure	Time frame
HbA1c level, Body weight	—

Countries

Japan

Contacts

Public ContactTakeshi Yamamoto

Showa University of medicine the department of internal medicine, the division of diabetology, metabolism and endocrinology

tak3105@med.showa-u.ac.jp03-3784-8947

Outcome results