knee osteoarthritis rheumatoid arthritis
Conditions
Interventions
Study group:Fentanyl sustained intravenous administration given after operation end. And use the Intravenous acetaminophen 4 times per 6 hour.Dosage is 15 mg/kg for the patient less than 50 kg in weig
Sponsors
Yamaguchi University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Subjects eligible for inclusion in this study have to fulfill all of following criteria and be judged eligible for the study by the investigator. 1) Those who have ability to provide written consent to participate in the study. 2)Patients of American Society of Anesthesiologists (ASA) physical status classification 1 and 2 and 3. 3)Patients aged 20 years or older at the time of obtaining informed consent.
Exclusion criteria
Exclusion criteria: 1)Aspirin-induced asthma or a history of diseases of aspirin-induced asthma. 2)Any subject with a past history of anaphylaxis due to acetaminophen. Any subject with blood abnormality, hepatopathy, kidney damage or cardiac dysfunction. 3)patients with liver failure. 4)Patients with NSAIDS contraindications 5)Women who are pregnant, maybe pregnant or lactation. 6)Any subject with blood abnormality, hepatopathy, kidney damage or cardiac dysfunction. 7)Any condition that, in the opinion of the investigator, would make the patient unsuitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity at rest is measured with NRS for 24 hours after surgery. | — |
Countries
Japan
Contacts
Public ContactKazushige Seki
Yamaguchi University Graduate School of Medicine Department of Orthopedic Surgery
Outcome results
None listed