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A prospective multicenter randomized controlled trial for the effect of high-dose corticosteroid on refractory Mycoplasma Pneumoniae pneumonia in children

A prospective multicenter randomized controlled trial for the effect of high-dose corticosteroid on refractory Mycoplasma Pneumoniae pneumonia in children - Effect of corticosteroid on Mycoplasma Pneumoniae pneumonia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000031674
Enrollment
46
Registered
2018-10-01
Start date
2018-08-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mycoplasma Pneumoniae pneumonia

Interventions

Low dose cohot Initial dose of prednisolone 1mg/kg/day High dose cohot Initial dose of prednisolone 2mg/kg/day

Sponsors

Nagoya University Graduate School of Medicine, Department of Pediatrics / Developmental Pediatrics
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Pediatric patients with Mycoplasma Pneumoniae pneumonia who are refractory to at least 2 types of antibiotics.

Exclusion criteria

Exclusion criteria: Patients 1.who need intubation by respiratory failure 2.who do not receive enough antibiotics therapy(at least by 2 groups of antibiotics ;Macrolid, Newquinolone or tetracycline) 3.who receive steroid therapy except for refractory Mycoplasma Pneumoniae pneumonia (such as asthma) who diagnosed as other diseases, such as HPS or Kawasaki Disease. 4.with Congenital heart diseases, metabolic disorder, neurologic dis order, bronchopulmonary disorder, or immune deficiency 5.who have allery of steroid 6.who is negative in immune-serological verification

Design outcomes

Primary

MeasureTime frame
The duration of fever from the start of steroid therapy

Secondary

MeasureTime frame
Relapse of fever, the duration of hospitalization, reduction rate of LDH and CRP

Countries

Japan

Contacts

Public ContactJunichi Kawada

Nagoya University Graduate School of Medicine Department of Pediatrics / Developmental Pediatrics

kawadaj@med.nagoya-u.ac.jp+81-52-741-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026