Esophageal squamous cell carcinoma
Conditions
Interventions
None listed
Sponsors
Tohoku University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) disease name Esophageal cancer squamous cell carcinoma not treated (2) stage cT3 - T4, lymph node metastasis or distant metastasis (UICC 7th edition) (3) Age 20 years old, under 79 years (when registering) (4) Gender There is no problem in gender. (3) Performance Status 0-3 (4) Multiple cases of active duplication cancer. (5) Bone marrow and organ function that satisfy the following conditions are preserved, and it can be predicted that radiation chemotherapy for simultaneous combination can be performed. WBC 3000 / m 3 or more, PLT 100000 / m 3 or more, Hb 10 g / dl or more AST 75 IU / l or less, ALT 75 IU / l or less, T-Bil 1.5 mg / dl or less Cr: 1.2 mg / dl or less, Ccr (measured value): 50 ml / min / body or more (6) With regard to participation in this clinical trial, his / her consent has been obtained in writing. (7) Gastrointestinal disorder Treatment was selected by consultation of the department of gastroenterology, gastrointestinal surgery, tumor internal medicine, radiotherapy department in consideration of past history, internal organs function, patient's and family's desire Case.
Exclusion criteria
Exclusion criteria: (1) Patients with history of chemotherapy or radiotherapy to the chest against esophageal cancer or other diseases. (2) Cases after esophagus cancer mucosal resection. (3) Simultaneous duplicated cancer cases of active requiring treatment. Or cases with a disease-free period of less than 3 years even if they are metachronous. (4) Cases with severe complications such as poorly controlled diabetes, collagen diseases, heart diseases, lung diseases, kidney diseases, psychiatric disorders and the like which are expected to be unable to withstand the present test protocol (5) Pregnant women, lactating women and cases of possible pregnancy. (6) Cases in which active infection has been proven and has a fever of 38 degrees or more. (7) Cases in which steroids are routinely used. (8) Case with pacemaker or internal defibrillator. (9) Cases in which confirmation of intention can not be performed. (10) Cases in which MRI imaging can not be performed. (11) Other cases that the doctor in charge deemed inappropriate as a subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relationship between changes within the 14 days before radiochemotherapy by ADC value measurement and at 20 Gy point after treatment start and tumor reduction ratio | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival rate and relapse-free survival rate and prognostic factors | — |
Countries
Japan
Contacts
Public ContactYu Suzuki
Tohoku University Graduate School Graduate School of Medicine Department of Radiation Oncology
Outcome results
None listed