The effect of propofol on H Reflex, M wave and motor evoked potential.

The effect of propofol on H Reflex, M wave and motor evoked potential. - The effect of propofol on H Reflex, M wave and motor evoked potential.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000031650

Enrollment

Registered

2018-03-19

Start date

2018-03-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who are scheduled for spine surgery by posterior approach requiring neurophysiological monitoring under general anesthesia

Interventions

Measurement of H Reflex, M wave, F wave, and motor evoked potentials at three effect site concentrations (2.0, 3.0 and 4.0 mcg/ml) of propofol.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients who are scheduled for spine surgery by posterior approach requiring intraoperative neurophysiological monitoring.

Exclusion criteria

Exclusion criteria: ASA PS 4 or 5. Previous history of epilepsy, cerebrovascular diseases History of neuromuscular disorders including myasthenia gravis, lower extremity peripheral nerve dysfunction, severe heart disease. Those who can not understand the purpose of this study such as dementia. Those who are allergic to the drugs to be used. Those who are judged unsuitable by the research doctor.

Design outcomes

Primary

Measure	Time frame
The amplitude of H reflex of left soleus muscle at propofol effect site concentration 2.0 and 4.0 mcg/ml.	—

Secondary

Measure	Time frame
The amplitude and latency of motor evoked potential, M wave and F wave in bilateral soleus muscle at three propofol concentration(effect site concentrations 2.0, 3.0 and 4.0 mcg/ml). The amplitude and latency of H Reflex in left soleus muscle at propofol concentration(effect site concentrations) 3.0 mcg/ml. The latency of H Reflex in left soleus muscle at three propofol concentration(effect site concentrations 2.0, 3.0 and 4.0 mcg/ml). The amplitude and latency of H Reflex in right soleus muscle at three propofol concentration(effect site concentrations 2.0, 3.0 and 4.0 mcg/ml). The amplitude and latency of motor evoked potential in bilateral abductor pollicis brevis, bilateral quadriceps, bilateral tibialis anterior, bilateral abductor hallucis and bilateral hamstrings at three propofol concentration(effect site concentrations 2.0, 3.0 and 4.0 mcg/ml). The amplitude and latency of posterior tibial nerve somatosensory evoked potential at three propofol concentration(effect site concentrations 2.0, 3.0 and 4.0 mcg/ml).	—

Measure

Time frame

The amplitude and latency of motor evoked potential, M wave and F wave in bilateral soleus muscle at three propofol concentration(effect site concentrations 2.0, 3.0 and 4.0 mcg/ml). The amplitude and latency of H Reflex in left soleus muscle at propofol concentration(effect site concentrations) 3.0 mcg/ml. The latency of H Reflex in left soleus muscle at three propofol concentration(effect site concentrations 2.0, 3.0 and 4.0 mcg/ml). The amplitude and latency of H Reflex in right soleus muscle at three propofol concentration(effect site concentrations 2.0, 3.0 and 4.0 mcg/ml). The amplitude and latency of motor evoked potential in bilateral abductor pollicis brevis, bilateral quadriceps, bilateral tibialis anterior, bilateral abductor hallucis and bilateral hamstrings at three propofol concentration(effect site concentrations 2.0, 3.0 and 4.0 mcg/ml). The amplitude and latency of posterior tibial nerve somatosensory evoked potential at three propofol concentration(effect site concentrations 2.0, 3.0 and 4.0 mcg/ml).

—

Countries

Japan

Contacts

Public ContactHiroyuki Deguchi

Niigata University Graduate School of Medical and Dental Sciences Division of Anesthesiology

asabekkamu1@gmail.com025-227-2328

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026