diseases in the uterine cavity (ex: uterine myoma, endometrial polyp, uterine corpus cancer, endometrial hyperplasia)
Conditions
Interventions
3 hours before operation, patients will take the 5-aminolevulinic acid(20 mg/kg) once. 3 hours later, they will be performed photodynamic diagnosis under the hysteroscopy. During the operation, they
ll resect other lesions under the white light if we can find any in addition. When the resection is finished, we will do curettage if we need. We will investigate all samples histopathologically.
Sponsors
Keio University School of Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Patients who have diseases in the uterine cavity (including both of benign and malignant). Patients who plan to undergo hysteroscopic operation for those diseases at the Department of Obstetrics and Gynecology of Keio University Hospital
Exclusion criteria
Exclusion criteria: 1. under 20 years old 2. BMI>30 Patients who have 3. the medical history of full endometrial curettage in recent 14 days. 4. the allergic history for the analog of the porphyrin. 5. the history of porphyria 6. the medicine that is known for the cause of photosensitivity (ex. tetracycline antibacterial agent, medicine of sulfonamide, new quinolone antibacterial agent, hypericin and St.John's Wort. 7. the possibility of being pregnant or breast feeding 8. diabetes mellitus and/or hyperlipidemia which is not controlled. 9. other endocrine diseases which are not controlled. 10. Patients who are considered inadequate for this trial by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy of the hysteroscopic photodynamic diagnosis using 5-ALA for malignant diseases. | — |
Secondary
| Measure | Time frame |
|---|---|
| The relation of the histologic type and the strength of the fluorescence. | — |
Countries
Japan
Contacts
Public ContactYusuke Matoba
Keio University School of Medicine Department of Obstetrics and Gynecology
Outcome results
None listed