epilepsy
Conditions
Interventions
Sponsors
Yokohama City University hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with epilepsy on the basis of ILAE criteria 2. Patients who have seizures 12months prior to registration 3. Patients without neurosurgery in the past 4. Patients who are over 20 years and below 60 years 5. Patients who can consent to this study by oneself
Exclusion criteria
Exclusion criteria: 1. Patients who have experienced the electric stimulation therapy 2. Patients who have severe renal dysfunction (Serum Cre>1.5) 3. Patients who have severe liver dysfunction (AST and ALT>150) 4. Patients who have severe cardiovascular disorder 5. Patients who have tatoo 6. Claustrophobic patients 7. Patients who can not agree with contraception during 7days after [11C]K-2 PET 8. Patients who take Perampanel or Topiramate(within 1month before this registration) 9.Patients who underwent nuclear medicine examination within 1 week before this registration 10.Patients who underwent other clinical trials using unapproved nuclear medicine examination within 6 months before this registration 11.Patients who underwent other clinical trial within 12 weeks before this registration 12.Patients whom study doctors consider inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To examine the differences in the distributions of AMPARs among the groups divided by seizure pattern in comparison with those of healthy subjects. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To examine the differences in the distributions of AMPARs between the groups divided by seizure pattern in comparison with their FDG-PET data. 2. To examine the correlation in the expected foci between those identified by AMPA-PET and EEG/MEG. | — |
Countries
Japan
Contacts
Public ContactSayoko Nakashima
Yokohama City University hospital YCU Center for Novel and Exploratory Clinical Trials
Outcome results
None listed