Effect of canagliflozin as an alternative drug from DPP-4 inhibitor on heart failure with diabetis melltus : the pilot study "Can canagliflozin HAve Not only hypoGlycemic but cardiac supportive Effect?"

Effect of canagliflozin as an alternative drug from DPP-4 inhibitor on heart failure with diabetis melltus : the pilot study "Can canagliflozin HAve Not only hypoGlycemic but cardiac supportive Effect?" - CHANGE trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000031563

Enrollment

Registered

2018-03-04

Start date

2018-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic heart failure with type 2 diabetis mellitus

Interventions

Change group: Start with canagliflozin 100mg/day and stop or reduce DPP-4 inhibitor for 6 months. Non-Change group: Conventional therapy for diabetes and heart failure

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Treated with DPP4 inhibitor 2. Heart failure patients with type 2 diabetes mellitus who have HbA1c 6.5% or more

Exclusion criteria

Exclusion criteria: 1. End stage renal failure including eGFR<15ml/min/1.73m2 or dialytic therapy 2. Treated with SGLT2 inhibitor 3. Contraindications of SGLT2 inhibitor 4. Type 1 diabetes mellitus 5. The pregnant, breast feeder 6. BMI<18.5kg/m2

Design outcomes

Primary

Measure	Time frame
the change of BNP at 6 months from baseline	—

Secondary

Measure	Time frame
1. Vital signs 2. Labolatory data: blood and urinary biomarkers 3. Cardiac function 4. Cardiac vascular event	—

Countries

Japan

Contacts

Public ContactKyosuke Yanagawa

Osaka Rosai Hospital Division of Cardiology

k.yanagawa0217@osakah.johas.go.jp072-252-3561

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

Effect of canagliflozin as an alternative drug from DPP-4 inhibitor on heart failure with diabetis melltus : the pilot study &quot;Can canagliflozin HAve Not only hypoGlycemic but cardiac supportive Effect?&quot;