Comparison of Alogliptin and Metformin fixed-dose tablets once a morning vs. once an evening using Freestyle Libre Pro flash glucose Monitoring (AMPM study): An open-label randomized cross-over Trial.

Comparison of Alogliptin and Metformin fixed-dose tablets once a morning vs. once an evening using Freestyle Libre Pro flash glucose Monitoring (AMPM study): An open-label randomized cross-over Trial. - Comparison of Alogliptin and Metformin fixed-dose tablets once a morning vs. once an evening using Freestyle Libre Pro flash glucose Monitoring (AMPM study): An open-label randomized cross-over Trial.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000031445

Enrollment

Registered

2018-02-23

Start date

2017-12-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes

Interventions

Morning treatment alogliptin benzoate and metformin hydrochloride combination tablets medication Evening treatment alogliptin benzoate and metformin hydrochloride combination tablets medication

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Age 20-70 years 2) Type 2 diabetes 3) HbA1c > 6.5%

Exclusion criteria

Exclusion criteria: 1) Type 1 diabetes 2) Undergoing insulin or GLP-1 agonist treatment 3) shift worker or night worker 4) Contraindications of medicine (Cr => 1.3mg/dL for men and => 1.2mg/dL for women) 5) Patients have History of hyper sensitivity 6) Not suitable for paticipate in this study from medical reason judged by a doctor

Design outcomes

Primary

Measure	Time frame
To compare the blood glucose area under the curve	—

Secondary

Measure	Time frame
1) Average glucose (AG) 2) Average daily risk range (ADRR) 3) Morbus (M) value 4) 3-h post prandial (breakfast, lunch, dinner) blood glucose area under the curve (AUC) 5) Blood glucose (< 70mg/dl) area on the curve (AOC)	—

Countries

Japan

Contacts

Public ContactEbara Futoshi

Iryohojin Sukoyaka Takadachuo Byoin Department of the internal medicine

japansk@nifty.com+81-45-592-5557

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026