Obesity population
Conditions
Interventions
The tasteless and odorless gum was chewed for 5 minutes, and the cerebral blood flow dynamics and hemodynamics after chewing are compared and examined. During gum chewing, glucose 75 g solution is or
Sponsors
Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Participants are recruited from the students of Tokyo medical and dental university.
Exclusion criteria
Exclusion criteria: They fulfilled following exclusion criteria: (i) history of metabolic, neurological, or psychiatric diseases or any eating disorders, (ii) use of any medication, (iii) current or recent efforts to lose weight, (iv) pregnant, (v) BMI > 25 kg/m2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in cerebral blood flow dynamics after administration of glucose solution are compared and examined with or without chewing. All subjects conduct experiments on different days under chewing conditions or control conditions (without chewing). Brain function measurement is performed by functional MRI imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| Regarding blood tests, subjects took a total of 7 blood draws before gum chewing (5 minutes before glucose administration in control experiments) and immediately after glucose administration (0), 10, 20, 30, 40 and 50 minutes . At that time, the concentrations of glucose, insulin, leptin, ghrelin, PYY (peptide YY), GLP-1 (glucagon-like peptide 1), GIP (glucose-dependent secretion stimulating polypeptide), CCK (cholecystokinin) are measured. | — |
Countries
Japan
Contacts
Public ContactJun J Miyamoto
Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction
Outcome results
None listed