The Relation between Impairment of Endothelium-dependent Coronary Blood Flow Volume Change and Higher Platelet Aggregability

The Relation between Impairment of Endothelium-dependent Coronary Blood Flow Volume Change and Higher Platelet Aggregability - Endothelial function and platelet aggregability

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000031390

Enrollment

Registered

2018-02-28

Start date

2012-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy person

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The study screened stable patients suspected angina who admitted Kumamoto Univercity Hospital between January 2002 to April 2011. We performed coronary angiography (CAG), intracoronary acetylcholine-provocation test and measured coronrary flow reserve (CFR) to diagnose angina, and we excluded patients with ischemic heart disease (IHD) and vasospastic angina. Then we also excluded patients with took antithrombotic drugs. We finally enrolled 25 patients without obstructive or spastic angina were assessed the relation between CBFV and platelet aggregability.

Exclusion criteria

Exclusion criteria: we excluded patients who take any anti-platelet agents from 62 patients with non-obstructive IHD.

Design outcomes

Primary

Measure	Time frame
Consecutive 368 patients suspected angina with normal coronary arteries were initially enrolled. We performed coronary angiography and intracoronary acetylcholine-provocation test, and measured adenosine triphosphate-induced coronary flow reserve (CFR) to diagnose the presence of non-obstructive IHD by using Doppler FloWire at the proximal site of left anterior descending coronary artery before taking any vasodilators at the basal non-stress condition. Then, we excluded patients who take any anti-platelet agents from 62 patients with non-obstructive IHD. Finally, 25 non-obstructive IHD patients were assessed the relation between CBFV change and platelet aggregability as P2Y12 reaction unit (PRU) by VerifyNow P2Y12 assay system.	—

Measure

Time frame

Consecutive 368 patients suspected angina with normal coronary arteries were initially enrolled. We performed coronary angiography and intracoronary acetylcholine-provocation test, and measured adenosine triphosphate-induced coronary flow reserve (CFR) to diagnose the presence of non-obstructive IHD by using Doppler FloWire at the proximal site of left anterior descending coronary artery before taking any vasodilators at the basal non-stress condition. Then, we excluded patients who take any anti-platelet agents from 62 patients with non-obstructive IHD. Finally, 25 non-obstructive IHD patients were assessed the relation between CBFV change and platelet aggregability as P2Y12 reaction unit (PRU) by VerifyNow P2Y12 assay system.

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Countries

Japan

Contacts

Public ContactMasafumi Takae

Kumamoto univercity hospital cardiology

qqcv2t3d@yahoo.co.jp0963735175

Outcome results