Men and women
Conditions
Interventions
None listed
Sponsors
Hiyoshi Oral Health Clinics
Lion Corporation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (A-1) Males and females aged 20 to 65 years old. (A-2) Subjects who don't regularly use specific medicines. (A-3) Subjects who show understanding of the study procedures and agreement with participating the study by written informed consent prior to the study. (B-1) Males and females aged 20 to 79 years old. (B-2) Subjects who are found carious pit that are required therapy in adult tooth by visual or X-ray. (B-3) Subjects who show understanding of the study procedures and agreement with participating the study by written informed consent prior to the study. (C-1) Males and females aged 20 to 79 years old. (C-2) Subjects who have at least 1 periodontal pockets that are 4 mm or deeper with bleeding. (C-3) Subjects who do not have carious pit. (C-4) Subjects who show understanding of the study procedures and agreement with participating the study by written informed consent prior to the study. (D-1) Males and females aged 20 to 79 years old. (D-2) Subjects who do not have periodontal pockets that are 4 mm or deeper. (D-3) Subjects who have 10% or less bleeding tooth surface. (D-4) Subjects who do not have carious pit. (D-5) Subjects who show understanding of the study procedures and agreement with participating the study by written informed consent prior to the study. (E-1) Males and females aged 80 to 100 years old. (E-2) Subjects who have 26 or greater original teeth. (E-3) Subjects who did not receive treatment of carious or periodontal disease during last 10 years. (E-4) Subjects who show understanding of the study procedures and agreement with participating the study by written informed consent prior to the study.
Exclusion criteria
Exclusion criteria: (A-1) Subjects who have denture or implants. (A-2) Smoker (A-3) Subjects who consumed antibiotics during last 6 months. (A-4) Subjects who did mouth cleaning, eating, or drinking except water during last 1 hour. (A-5) Subjects who did mouth cleaning from last night to sampling. (A-6) Subjects who is pregnant. (A-7) Subjects who have been determined ineligible by principal investigator. (B-1) Subjects who have denture or implants. (B-2) Smoker (B-3) Subjects who consumed antibiotics during last 6 months. (B-4) Subjects who is in orthodontic treatment. (B-5) Subjects who did mouth cleaning, eating, or drinking except water during last 1 hour. (B-6) Subjects who is pregnant. (B-7) Subjects who have been determined ineligible by principal investigator. (C-1) Subjects who have denture or implants. (C-2) Smoker (C-3) Subjects who consumed antibiotics during last 6 months. (C-4) Subjects who is in orthodontic treatment. (C-5) Subjects who did mouth cleaning, eating, or drinking except water during last 1 hour. (C-6) Subjects who is pregnant. (C-7) Subjects who have been determined ineligible by principal investigator. (D-1) Subjects who have denture or implants. (D-2) Smoker (D-3) Subjects who consumed antibiotics during last 6 months. (D-4) Subjects who is in orthodontic treatment. (D-5) Subjects who did mouth cleaning, eating, or drinking except water during last 1 hour. (D-6) Subjects who is pregnant. (D-7) Subjects who have been determined ineligible by principal investigator. (E-1) Subjects who did mouth cleaning, eating, or drinking except water during last 1 hour. (E-2) Subjects who have been determined ineligible by principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 16S rRNA gene-based metagenome analysis and metabolome analysis of oral cavity samples | — |
Secondary
| Measure | Time frame |
|---|---|
| * 16S rRNA gene-based metagenome analysis and metabolome analysis of fecal samples * Background research * Questionnaire | — |
Countries
Japan
Contacts
Public ContactShinnosuke Murakami
Metabologenomics, Inc. Headquarters
Outcome results
None listed