Evaluation of limb muscle and diaphragm atrophy in critically ill patients

Evaluation of limb muscle and diaphragm atrophy in critically ill patients - Limb muscle and diaphragm atrophy

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000031316

Enrollment

106

Registered

2018-02-15

Start date

2018-02-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients admitted in the ICU

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: We consecutively recruited adult patients who were expected to remain in the ICU more than 3 days.

Exclusion criteria

Exclusion criteria: We excluded patients who fell under one or more of the following categories: exhibiting trauma to or amputation of limbs; diagnosed with primary neuromuscular disease.

Design outcomes

Primary

Measure	Time frame
The change of thickness and cross-sectional area about limb muscle and diaphragm on days 1, 2, 3, 5, 7,and 10 with serial ultrasonographic measurements after ICU admission	—

Secondary

Measure	Time frame
The change of following several parameters on days 1, 2, 3, 5, 7, and 10 after ICU admission Muscle strength by MRC score Muscle strength by hand dynamometer Thickening fraction of diaphragm by ultrasonography The change of intercostal muscle thickness by ultrasonography Texture analysis of limb and diaphragm muscle by ultrasonography Muscle mass by bioelectrical impedance analysis FSS-ICU and ICU mobility Scale Titin in urine Biomarker in urine and blood	—

Measure

Time frame

The change of following several parameters on days 1, 2, 3, 5, 7, and 10 after ICU admission Muscle strength by MRC score Muscle strength by hand dynamometer Thickening fraction of diaphragm by ultrasonography The change of intercostal muscle thickness by ultrasonography Texture analysis of limb and diaphragm muscle by ultrasonography Muscle mass by bioelectrical impedance analysis FSS-ICU and ICU mobility Scale Titin in urine Biomarker in urine and blood

—

Countries

Japan

Contacts

Public ContactNobuto Nakanishi

Tokushima university hospital Emergency and critical care medicine

nobuto_nakanishi@yahoo.co.jp088-633-9347

Outcome results