Ulcerative colitis
Conditions
Interventions
None listed
Sponsors
Keio University Division of Gastroenterology and Hepatology, Department of Internal Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Men and women aged 20 years and over. Patients diagnosed with mild or moderate ulcerative colitis. Patients scheduled to undergo colonoscopy. Patients taking at least 5-ASA preparation at the same dose for 8 weeks or more at the time of endoscopy Patients who can obtain consent to participate in the examination by document. Patients who the doctor admitted to participate in this study
Exclusion criteria
Exclusion criteria: Patients who have been 6 weeks or more past relapse diagnosis. Patients with poor medication adherence for 5-ASA drugs Cases using 5-ASA topical therapy (suppository, enema preparation) within 1 week of endoscopy Patient who used steroid formulation (suppository, enema, oral steroid formulation, steroid injectable formulation) or biologic formulation within 2 weeks of endoscopic enrollment. Patients with Crohn's disease or peptic ulcer Patients with history of colorectal surgery Patients with severe renal and liver impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between 5-ASA concentration in colonic mucosa and colonic endoscopic activity | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between 5-ASA concentration in colonic mucosa and clinical symptoms (Partial UCDAI, DAI, Lichtiger index) | — |
Countries
Japan
Contacts
Public ContactMakoto Naganuma
Keio University Division of Gastroenterology and Hepatology, Department of Internal Medicine
Outcome results
None listed