Effect of the choice of postoperative maintenance infusion on patient prognosis:an open-label, randomized controlled trial.

Effect of the choice of postoperative maintenance infusion on patient prognosis:an open-label, randomized controlled trial. - Effect of postoperative maintenance transfusion on patient prognosis.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000031160

Enrollment

300

Registered

2018-02-05

Start date

2018-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative critically ill patients

Interventions

Saline + 5% glucose (same dose) will be administered at a rate of (body weight + 40) ml / h. Intervention period: From: Postoperative admission to the intensive care unit To: Postoperative day 3 (6

s solution will be administered at a rate of (body weight + 40) ml / h. Intervention period: From: Postoperative admission to the intensive care unit To: Postoperative day 3 (6:00 AM) Maintenance s

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients aged 20 years or older. 2) Patients who will undergo elective esophageal cancer surgery or elective head and neck cancer surgery. 3) Patients requiring postoperative intensive care for 48 hours or more.

Exclusion criteria

Exclusion criteria: 1) Patients with preoperative eGFR <= 50 ml / min. 2) Patients with preoperative total bilirubin value >= 2 mg / dL. 3) Patients with a history of heart failure 4) Pregnant women and patients who may be pregnant or breast-feeding patients. 5) Patients who are judged to be inappropriate.

Design outcomes

Primary

Measure	Time frame
Incidence of hyponatremia (serum Na concentration less than 136 mmol/L) 3 days after surgery.	—

Secondary

Measure	Time frame
1) Changes in serum vasopressin concentration, cortisol concentration, serum BNP concentration and urinary electrolyte concentration immediately after surgery and on the 1st to 3rd postoperative days. 2) Changes in serum S100 beta concentration and serum neuron-specific enolase concentration immediately after surgery and on the 1st to 3rd postoperative days. 3) Incidence of postoperative delirium during stay in the ICU. 4) Incidence and severity of postoperative organ injury during stay in the ICU 5) ICU-free survival days for 28 days after surgery.	—

Measure

Time frame

1) Changes in serum vasopressin concentration, cortisol concentration, serum BNP concentration and urinary electrolyte concentration immediately after surgery and on the 1st to 3rd postoperative days. 2) Changes in serum S100 beta concentration and serum neuron-specific enolase concentration immediately after surgery and on the 1st to 3rd postoperative days. 3) Incidence of postoperative delirium during stay in the ICU. 4) Incidence and severity of postoperative organ injury during stay in the ICU 5) ICU-free survival days for 28 days after surgery.

—

Countries

Japan

Contacts

Public ContactMoritoki Egi

Kobe university graduate school of medicine Division of anesthesiology, Department of suegery related,

moriori@tg8.so-net.ne.jp078-382-6172

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026