Clinical significance of 18F-Sodium Fluoride uptake for cardiovascular calcification on Positron Emission Tomography

Clinical significance of 18F-Sodium Fluoride uptake for cardiovascular calcification on Positron Emission Tomography - 18F-Sodium Fluoride uptake for cardiovascular calcification

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000031134

Enrollment

Registered

2018-02-04

Start date

2017-10-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic valve calcification, Aortic stenosis, Coronary plaque

Interventions

Combined PET/CT of the aortic valve and coronary plaque were performed within 1 month after cardiac CT imaging. The patients were injected intravenously with a target dose of 185-370MBq 18F-NaF and re

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: We include the patients with the following conditions. 1) Patients with coronary plaque (calcified plaque, non-calcified plaque and partial calcified plaque in >=2mm diameter coronary) or aortic valve calcification (CT value >=130HU) on coronary CT in Hiroshima University Hospital. 2) Patients over 30 years-old. 3) Patients without acute coronary syndromeand/or severe heart failure (within 3 months), or a unconscious condition. 4) Patients who agree with informed consent.

Exclusion criteria

Exclusion criteria: 1) Patients with bad general conditions, for example, immediately after cerebral hemorrhage. 2) Pregnant and lactating females (include possibility of them). 3) Claustrophobic patients. 4) Patients who are judged unsuitable for this study by the person in charge.

Design outcomes

Primary

Measure	Time frame
We compare 18F-Sodium Fluoride uptake of aortic valve, coronary artery, carotid artery and aorta on Positron Emission Tomography with coronary CT findings of aortic valve calcification, coronary calcification, and non-calcified and partial calcified plaques (positive remodeling, low attenuation plaque, spotty calcification and napkin-ring sign).	—

Secondary

Measure	Time frame
We evaluate serial changes of aortic valve calcification on CT in 2-year period. We classify 18F-NaF uptake pattern of aortic valve into three groups in relation to CT-based calcification; overlapping with calcification, adjacent to calcification and distant from calcification. Additionally, we evaluate the location of aortic valve calcification (valve leaflet or ring). We assess the progression of aortic valve calcification and aortic valve stenosis in relative to 18F-NaF uptake value and uptake pattern.	—

Measure

Time frame

We evaluate serial changes of aortic valve calcification on CT in 2-year period. We classify 18F-NaF uptake pattern of aortic valve into three groups in relation to CT-based calcification; overlapping with calcification, adjacent to calcification and distant from calcification. Additionally, we evaluate the location of aortic valve calcification (valve leaflet or ring). We assess the progression of aortic valve calcification and aortic valve stenosis in relative to 18F-NaF uptake value and uptake pattern.

—

Countries

Japan

Contacts

Public ContactToshiro Kitagawa

Hiroshima University Graduate School of Biomedical and Health Sciences Department of Cardiovascular Medicine

toshirok@hiroshima-u.ac.jp082-257-5555

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026