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Efficacy and safety of liraglutide for perioperative blood glucose control in diabetic subjects within enhanced recovery after surgery (ERAS) protocols

Efficacy and safety of liraglutide for perioperative blood glucose control in diabetic subjects within enhanced recovery after surgery (ERAS) protocols - Randomized prospective study for perioperative diabetes control within enhanced recovery after surgery (ERAS) protocols

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000031070
Enrollment
100
Registered
2018-01-31
Start date
2015-10-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes

Interventions

perioperative periods, liraglutide 0.9mg insulin therapy

Sponsors

Takatsuki redcross hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Adults (age 20 and above) with type 2 diabetes25 who received at least 3 months of previous antidiabetic treatment, had values of BMI over 20 kg/m2 inclusive with HbA1c 6.0% and above who were scheduled to undergo elective surgery within ERAS protocols were eligible

Exclusion criteria

Exclusion criteria: Patients who were to undergo gastrointestinal or neurosurgical procedures were excluded. Patients who tested positive for anti-GAD (glutamate decarboxylase) antibodies or with elevated ALT (2 times upper normal range) were excluded from the study. Patients with autonomic neuropathy or recurrent severe hypoglycemia were also excluded. Patients who had been administered any drug except for oral antidiabetic drugs (OADs), which could interfere with glucose level or bodyweight (i.e. systemic corticosteroids, orlistat or sibutramine), were also excluded. Patients who had been administered sGLT-2 inhibitor or thiazolidinediones were excluded because these medicines could interfere with accurate bodyweight changes

Design outcomes

Primary

MeasureTime frame
blood glucose fluctuation

Secondary

MeasureTime frame
insulin dosage and days prescribed for the correction of elevated blood glucose levels, frequency of hypoglycemic events, tolerance,changes in lean body mass, changes in body fat and visceral fat area

Countries

Japan

Contacts

Public ContactKaneko Shizuka

Takatsuki Redcross Hospital Diabetes, endocrinology and life-related disease

skayamoe@takatsuki.jrc.or.jp072-696-0571

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026