Crinical evaluation of zinc acetate for prevention of mucositis associated with radiotherapy in patients with head and neck cancer

Crinical evaluation of zinc acetate for prevention of mucositis associated with radiotherapy in patients with head and neck cancer - Crinical evaluation of zinc acetate for prevention of mucositis associated with radiotherapy in patients with head and neck cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030965

Enrollment

Registered

2018-01-29

Start date

2018-01-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

head and neck cancer

Interventions

oral medication of zinc acetate.medication starts from the beginning of radiation therapy.medication dose is 100mg/day,range 25-150mg associated with side effect of zinc acetate.medication period is 6

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) WHO PS 0-2 2) Advanced head and neck cancer,oral cavity is irradiated 3) Treated by radiotherapy and concomitant chemotherapy with cisplatin 4) Onset of mucositis is certain 5) Not diagnosted as dementia 6) Satisfy the diagnostic criteria of zinc deficiency(clinical and subclinical) advocated by japanese society of clinical nutrition

Exclusion criteria

Exclusion criteria: 1) Patients that subjective examination is difficult(i.e. patient with dementia, under 19 years old) 2) Patients under life-threatening situation. 3) Patients who is assesed by researcher as ungrammatical for this study

Design outcomes

Primary

Measure	Time frame
The worst grade of pharyngeal mucositis	—

Secondary

Measure	Time frame
Pharyngeal mucositis during radiation therapy of every week	—

Countries

Japan

Contacts

Public ContactTakehito Kishino

Kagawa university hospital Otolaryngology-Head and Neck Surgery

kissie@med.kagawa-u.ac.jp087-891-2214

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026