A phase 2 study of choledochojejunostomy in pagients with locally advanced pancreatic adenocarcinoma undergoing chemo-proton therapy.

A phase 2 study of choledochojejunostomy in pagients with locally advanced pancreatic adenocarcinoma undergoing chemo-proton therapy. - Choledochojejunostomy for pancreatic adenocarcinoma undergoing chemo-proton therapy.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030961

Enrollment

Registered

2018-01-24

Start date

2018-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

locally advanced pancreatic cancer

Interventions

Choledochojejunostomy before chemo-proton therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Locally advanced pancreatic cancer 2. Malignant bile duct ostruction 3. Pathologically confirmed adenocarcinoma / adenosquamous carcinoma 4. Age: >=20,80< 5. Aerformance Status (ECOG) 0/1 6. Sufficient function of important organs 7. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Past history of choledochojejunostomy 2. History of diseases which cause bile duct stenosis 3. Past history of abdominal irradiation 4. Inability of solid oral intake 5. Uncontrollable diabetes mellitus 6. Sever complication(heart failure, renal failure,liver failure,intestinal paralysis etc) 7. Acute coronary syndrome within 6 months, severe arrythmia 8. Consistent steroid use 9. Severe mental disorder 10. doctors decision not to be registered to this study

Design outcomes

Primary

Measure	Time frame
Incidence of unplanned delay or discontinuation of proton therapy	—

Countries

Japan

Contacts

Public ContactHirochika Toyama

Kobe University Graduate School of Medicine Division of Hepato-biliary-pancreatic Surgery Department of Surgery

tymhr@me.com078-382-6302

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026