Efficacy and applicability of respiratory muscle training on the balance of inspiratory-to-expiratory muscle strength and breathing timing in patients with chronic obstructive pulmonary disease: a preparatory research study

Efficacy and applicability of respiratory muscle training on the balance of inspiratory-to-expiratory muscle strength and breathing timing in patients with chronic obstructive pulmonary disease: a preparatory research study - Efficacy of respiratory muscle training for breathing timing in chronic obstructive pulmonary disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030937

Enrollment

Registered

2018-02-01

Start date

2018-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic obstructive pulmonary disease (COPD)

Interventions

1)All patients will be classified into two groups according to the change in Ti/Ttot during CPET. The patients in the Ti/Ttot increased group will receive inspiratory muscle training

the patients will receive inspiratory muscle training 30 times, twice per day for 3 months. The load of the respiratory training will be started at 20% of the maximum inspiratory pressure obtained at

The administration schedule of edible oil&gt

2.5 g of edible oil that comprises medium-chain C8 and C10 triglycerides will be administered orally, once daily, for 3 months. 1)All patients will be classified into two groups according to the cha

the patients will receive expiratory muscle training 30 times, twice per day for 3 months. The load of the respiratory training will be started at 20% of the maximum expiratory pressure obtained at ba

2.5 g of edible oil that comprises medium-chain C8 and C10 triglycerides will be administered orally, once daily, for 3 months.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Patients with moderate to very severe COPD (FEV1% < 70%, and %FEV1 < 80%, mMRC: grade 1and higher) 2)Patients whose conditions are stable and who are able to tolerate cardiopulmonary exercise testing to ensure adequate evaluation 3)Patients who have signed the agreement for participation in this study

Exclusion criteria

Exclusion criteria: 1)Patients with malignant tumors 2)Patients with active infection 3)Patients with severe heart disease 4)Patients with asthma 5)Patients whose drug regimen was changed during this study 6)Patients who receive pulmonary rehabilitation 7)Patients who receive oxygen therapy at rest 8)Patients who are undergoing diabetes mellitus therapy or whose HbA1C is >7.0 9)In addition to the above exclusion criteria, patients judged by their physician to be inadequate to participate in this study

Design outcomes

Primary

Measure	Time frame
Exertional changes in breathing timing (Ti/Ttot)	—

Secondary

Measure	Time frame
1.Symptom (CAT score, SGRQ score) 2.Body weight, Body Mass Index 3.Respiratory function (FEV1, %FEV1, FEV1%, VC, and %VC) 4.Forced oscillation technique (resistance and reactance) 5.The following parameters in cardiopulmonary exercise testing (CPET): minute ventilation (VE), oxygen uptake (VO2), carbon dioxide output (VCO2), breathing frequency (fR), tidal volume (VT), physiologic dead space/tidal volume ratio (VD/VT), dyspnea intensity (Borg scale), and exercise time 6.Respiratory muscle pressure (MIP), maximum inspiratory pressure (MIP), minimum expiratory pressure (MEP), \|MIP\|/MEP 7.Dual-energy X-ray absorptiometry (DEXA)	—

Measure

Time frame

1.Symptom (CAT score, SGRQ score) 2.Body weight, Body Mass Index 3.Respiratory function (FEV1, %FEV1, FEV1%, VC, and %VC) 4.Forced oscillation technique (resistance and reactance) 5.The following parameters in cardiopulmonary exercise testing (CPET): minute ventilation (VE), oxygen uptake (VO2), carbon dioxide output (VCO2), breathing frequency (fR), tidal volume (VT), physiologic dead space/tidal volume ratio (VD/VT), dyspnea intensity (Borg scale), and exercise time 6.Respiratory muscle pressure (MIP), maximum inspiratory pressure (MIP), minimum expiratory pressure (MEP), |MIP|/MEP 7.Dual-energy X-ray absorptiometry (DEXA)

—

Countries

Japan

Contacts

Public ContactKeisuke Miki

National Hospital Organization Toneyama National Hospital Department of Respiratory Medicine

mikisuke@toneyama.go.jp06-6853-2001

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026