Patients more than or equal to 65 years old, who undergo cardiovascular surgery for valvular or coronary artery diseases under cardiopulmonary bypass with cardiac arrest
Conditions
Interventions
Intervention: Infusion of dexmedetomidine immediately after ICU admission until 2 postoperative day(0.1-0.15 microgram/kg/hr)
Control: Infusion of normal saline immediately after ICU admission until
Sponsors
Department of Anesthesiology, Keio University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients more than or equal to 65 years old, who undergo cardiovascular surgery for valvular diseases or coronary artery diseases under cardiopulmonary bypass with cardiac arrest
Exclusion criteria
Exclusion criteria: Patients diagnoses as schizophrenia or depression Patients with liver cirrhosis Patients under dialysis management Patient with heart rate less than 50/min Patients with severe dementia Patient without communication ability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium until 2 postoperative day | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of delirium until 5 postoperative day The rate of haloperidol or risperidone use for delirium The duration of invasive mechanical ventilation The rate and duration of noninvasive ventilation The rate of intra-aortic balloon pumping or extracorporeal membrane oxygenation management The rate of duration in which the targetted sedation level evaluated by Richmond agitation sedation scale was achieved The dose of catecholamines used The rate and volume of blood transfusion The degree of pain evaluated by Numerical rating scale during ICU stay Cognitive function evaluated by Mini mental state examination at 7 postoperative day Duration of ICU stay | — |
Countries
Japan
Contacts
Public ContactHiromasa Nagata
Keio University School of Medicine Department of Anesthesiology
Outcome results
None listed