Efficacy and safety of high-protein early enteral nutrition in critically ill patients with respiratory failure, single-center prospective randomized control trial

Efficacy and safety of high-protein early enteral nutrition in critically ill patients with respiratory failure, single-center prospective randomized control trial - High-protein enteral nutrition in critically ill patients with respiratory failure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030866

Enrollment

Registered

2018-01-17

Start date

2018-01-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

critically ill patients requiring mechanical ventilation

Interventions

High-protein enteral nutrition for 7 days (1.2 to 1.5 g/kg/day) Standard enteral nutrition for 7 days (0.6 to 1.2 g/kg/day)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Critically ill patients with respiratory failure initiating enteral nutrition within 48 hours after admission to intensive care unit

Exclusion criteria

Exclusion criteria: (1)Patients with unstable hemodynamics requiring repeated increase of noradrenaline dosage (2)Patients with chronic kidney disease not undergoing dialysis or not planning to undergo dialysis (3)Patients having problems (active gastrointestinal bleeding, ileus or short-bowel syndrome) for administration of enteral nutrition

Design outcomes

Primary

Measure	Time frame
In-hospital mortality	—

Secondary

Measure	Time frame
Rate of combination parenteral nutrition Incidence rate of metabolic adverse effects Total insulin dosage Duration of ICU and hospital stay Duration of mechanical ventilation	—

Countries

Japan

Contacts

Public ContactTakashi Ogasawara

Hamamatsu medical center Department of respiratory medicine

shikatarawasagao@gmail.com0534537111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026