Evaluation of the disolution and palatability of amlodipine orally disintegrating tablet in oral cavity for development of quantitative evaluation methods of palatability by an electronic gustatory system

Evaluation of the disolution and palatability of amlodipine orally disintegrating tablet in oral cavity for development of quantitative evaluation methods of palatability by an electronic gustatory system - Disolution in the oral cavity and palatability of amlodipine orally disintegrating tablet

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030831

Enrollment

Registered

2018-01-16

Start date

2018-01-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteers

Interventions

COAO:Amlodipine ODT without taste-masking C4A0:Physical masking(4%) of Amlodipine ODT C6A0:Physical masking(6%) of Amlodipine ODT C6A2:Physical masking(6%) of Amlodipine ODT with a sweetener(2%) C6A4:

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adult

Exclusion criteria

Exclusion criteria: 1. Clearly taste disorder 2. Allergy for drugs 3. Pregnant and/or lactating women 4. Other who was decided as inadequate by doctor

Design outcomes

Primary

Measure	Time frame
The relationship between the clinical VAS scores of palatability in the human gustatory sensation test and the electronic gustatory system	—

Secondary

Measure	Time frame
Elution volume of amlodipine in the oral cavity Saliva volume VAS score(overall palatability) VAS score(bitterness/sweetness) 5-point scale(palatability)	—

Countries

Japan

Contacts

Public ContactChiaki Kamiya

Hamamatsu University School of Medicine Department of Clinical Pharmacology and Therapeutics

ilka122@hama-med.ac.jp053-435-2385

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026