Skip to content

Multi-center randomized controlled trial to evaluate oral vitamin B12 treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients

Multi-center randomized controlled trial to evaluate oral vitamin B12 treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients - Multi-center randomized controlled trial to evaluate oral vitamin B12 treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000030727
Enrollment
160
Registered
2018-01-10
Start date
2018-01-11
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastric cancer

Interventions

Vitamin B12 1500 Vitamin B12 500

Sponsors

yokohama city university
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1:Histologically proven adenocarcinoma of the stomach and dignosed pathological stage I to III 2:Received R0 resection 3:Age ranging between 20 and 80 years 4:ECOG performance status 0-2 5:seremu vitamin B12 was under 200pg/ml 6:Peripheral neuropathy with vitamin B12 7:Sufficient oral intake 8:Sufficient organ function 9:Answer toPNQ test 10:Patients were given a written explanation of the study protocol and provided their written informed consent before participating.

Exclusion criteria

Exclusion criteria: 1:Synchronous or metachronous cancer (synchronous multiple cancers in the stomach included). 2:Allergic reaction to vitamin B12 3:Systemic treatment with vitamin B12 4:Peripheral neuropathy with other causes 5:Received adjuvant chemotherapy for gastric cancer 6:Any other medical conditions that made a patient unsuitable for inclusion in the study according to the opinion of the investigator were also considered to be exclusion criteria for this study

Design outcomes

Primary

MeasureTime frame
The incidence of vitamin B12 levels below 200 pg/ml after 12 weeks treatment

Countries

Japan

Contacts

Public Contacttoru aoyama

yokohama city university Department of surgery

t-aoyama@lilac.plala.or.jp045-787-2800

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026