Regulatory T cells and M2 polarized tumor-associated macrophages are associated with oncogenesis and progression of oral squamous cell carcinoma

Regulatory T cells and M2 polarized tumor-associated macrophages are associated with oncogenesis and progression of oral squamous cell carcinoma - Regulatory T cells and M2 polarized tumor-associated macrophages are associated with oncogenesis and progression of oral squamous cell carcinoma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000030670

Enrollment

120

Registered

2018-01-09

Start date

2018-01-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: OSCC or OEPL Stage1-4 Male or female (30yo-90yo)

Exclusion criteria

Exclusion criteria: Patients disagreing this test

Design outcomes

Primary

Measure	Time frame
In the present study, we examined the correlation between Treg and M2 TAM infiltration in OSCC and OEPL specimens based on the expression of M2 macrophage markers CD163 and CD204, and Treg markers CD25 and FoxP3 assessed by immunohistochemistry. Furthermore, we investigated the association between Treg and M2 TAM presence in tumors and clinicopathological characteristics of OSCC and OEPL patients.	—

Measure

Time frame

In the present study, we examined the correlation between Treg and M2 TAM infiltration in OSCC and OEPL specimens based on the expression of M2 macrophage markers CD163 and CD204, and Treg markers CD25 and FoxP3 assessed by immunohistochemistry. Furthermore, we investigated the association between Treg and M2 TAM presence in tumors and clinicopathological characteristics of OSCC and OEPL patients.

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Countries

Japan

Contacts

Public ContactAtsumu Kouketsu

Tohoku University Hospital Oral surgery

kouketsu_atsumu@dent.tohoku.ac.jp022-717-8350

Outcome results