Evaluation of PT-INR after eating reduced vitamin K2 Natto in patients who has warfarin treatment

Evaluation of PT-INR after eating reduced vitamin K2 Natto in patients who has warfarin treatment - PT-INR and reduced vitamin K2 Natto

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030521

Enrollment

Registered

2018-02-01

Start date

2018-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Warfarin treated patients

Interventions

Warfarin treated patients who eat low vitamin K2 Natto for 7 days. When 10g is acceptable, same patients will take 20g Natto.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patient who has bioprosthetic valve for valve replacement. PT-INR needs to be stable.

Exclusion criteria

Exclusion criteria: mechanical valve replacement. thrombosis history.

Design outcomes

Primary

Measure	Time frame
change of PT-INR will be evaluated before and after eating low vitamin K2 Natto for 7 days.	—

Countries

Japan

Contacts

Public ContactYuji Hiramatsu

University of Tsukuba Cradiovascular Surgery

yuji3@md.tsukuba.ac.jp029-853-3210

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026