patients undergoing open-heart surgery
Conditions
Interventions
Oral administraion of amino acid (abund) for 14-28 days
No intervention
Sponsors
Kobe university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing open-heart surgery in Kobe University Hospital. 1. Patietns with age greater than or equal to 65 years 2. Patients who agreed to study participants
Exclusion criteria
Exclusion criteria: 1. patients with BNP more than 500pg/ml. 2. patients with eGFR<30ml/min/1.73m2. 3. patients with T-Bil>2.0mg/dL 4. patients with congenital branched chain amino acid metabolism disorders 5. Patients whose consent was not obtained 6.Participation in any clinical research study evaluating another investigational drug or therapy within 4 months prior to randomization 7. presence of other conditions, which make the patient unsuitable for the study according to the judgment of the principal investigatoror or coinvestigator. 8. Patients who can not perform 6 minutes walking test 9. Patients who take amino acids supplements prior to randomization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference for change in 6-minute walk test distance between pre- and post-operation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Difference for incidence of postoperative complications. 2. Difference for changes in nutritional status. 3. Difference for change in physical function (grip strength, knee extensor muscle strength, body composition, short physical performance battery score, and physical activity estimates). 4. Difference in psychological, and health status. 5. Difference for changes in inflammatory status. 6. Difference for hospital mortality 7. Difference for hospital length of stay 8. Difference for ICU length of stay | — |
Countries
Japan
Contacts
Public ContactSeimi Kobayashi
Kobe university hospital Cardiovascular medicine
Outcome results
None listed