Parkinson'
Conditions
Interventions
The setting of deep brain stimulation is set to 0 mA as a placebo control.
To change 31 patterns of deep brain stimulation settings
Sponsors
Juntendo University Hospital
Kao Corporation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: -Parkinson's disease patients who was implanted bilaterally in STN with a DBS system (Vercise PC DBS System) for at least 3 months and was determined optimized programming according to standard care for at least 4weeks. The second or third segment electrode from the bottom is selected for optimized programming contact. The direction at the directional mode (0 degree, 120 degree, 240 degree) which causes pyramidal sign was identified during screening. -Diagnosed bilateral idiopathic Parkinson's disease -Subjects with written informed consent by their own will
Exclusion criteria
Exclusion criteria: -Any significant psychiatric problems including unrelated clinically significant depression -Any current drug or alcohol abuse -Any history of recurrent or unprovoked seizures. -Any significant medical condition that is likely to interfere with study procedures or likely to confound evaluation of study endpoints, including any terminal illness with survival less than 12 months. -Subjects with "the 3rd grade: red patient" in "the grade of fall risk" of Juntendo University Hospital -Subjects with large body frame expected not to be assisted by researchers in the case of their fall -Subjects who was considered inappropriate to participate in this study by the researchers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of steps and time on 6m walking and Time up and go test after the steering of deep brain stimulation | — |
Secondary
| Measure | Time frame |
|---|---|
| Gait parameters and side effect on 6m walking and Time up and go test using 3D gait analysis system after steering of deep brain stimulation and Unified Parkinson's disease rating scale partIII | — |
Countries
Japan
Contacts
Public ContactGenko Oyama
Juntendo University Hospital Department of Neurology
Outcome results
None listed