The effect of the blood concentrations of asymmetric dimethylarginine and arginine on the cerebrovascular CO2 reactivity during general anesthesia in the patients with chronic renal failure

The effect of the blood concentrations of asymmetric dimethylarginine and arginine on the cerebrovascular CO2 reactivity during general anesthesia in the patients with chronic renal failure - Cerebrovascular CO2 reactivity during general anesthesia in patients with chronic renal failure

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000030432

Enrollment

Registered

2017-12-17

Start date

2017-12-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

In principal, chronic renal failure patients (creatinine concentration equal or more than 4mg) for planning living-related renal transplantation patients under general anesthesia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Chronic renal failure cases caused by glomerulonephritis. 2. Cases whose blood creatinine concentrations are equal or more than 4mg/dL. 3. Cases who are undergoing renal plantation, arteriovenous shunt formation for hemodialysis and catheter implantation for continuous ambulatory peritoneal dialysis under general anesthesia. 4. Cases with controlled hypertension along with who criteria. 5. Control cases with American society of anesthesiologist physical status 1. 6. Control cases with estimated glomerular filtration rate equal or more than 60 ml/min/1.73m2. 7. Control cases who are undergoing nephrectomy or general surgery under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Cases whose hemoglobin concentrations are below 8g/dL. 2. Cases who cannot measure the blood flow velocity in middle cerebral artery by transcranial Doppler. 3. Laparoscopic surgery cases. 4. Emergency cases. 5. Cases with pregnancy. 6. Cases with uncontrolled hypertension. 7. Cases with atrial fibrillation, paroxysmal atrial fibrillation and premature ventricular contraction more than 10 times per minute. 8. History of cerebrovascular disease. 9. History of angina pectoris. 10. Chronic renal failure caused by diabetes mellitus, hypertension, gout, liver disease, drug induced and pregnancy. 11. Control cases with estimated glomerular filtration rate below 60 ml/min/1.73m2.

Design outcomes

Primary

Measure	Time frame
The comparison of CO2R between the chronic renal failure patients and patients without it during general anesthesia.	—

Secondary

Measure	Time frame
Evaluation of the effect of blood concentration of BUN, creatinine, asymmetric dimethylargininase (ADMA), L-Arginine and L-Arginine/ADMA ratio on CO2R in the chronic renal failure patients.	—

Countries

Japan

Contacts

Public ContactKazuyoshi Ishida

Yamaguchi University Graduate School of Medicine Department of Anesthesiology

ishid002@yamaguchi-u.ac.jp0836-22-2291

Outcome results