The evaluations of the incident rate of and risk factors for development of cognitive dysfunction in each surgical types of cardiovascular surgery

The evaluations of the incident rate of and risk factors for development of cognitive dysfunction in each surgical types of cardiovascular surgery - The development of and risk factor for postoperative cognitive dysfunction in cardiovascular surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000030428

Enrollment

300

Registered

2017-12-16

Start date

2017-12-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients for cardiovascular surgery

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Cases of aortic valve replacement, transcatheter aortic valve implantation, mitral valve replacement or plasty, surgery for major aorta (open surgery, stent graft implantation) and off -pump CABG.

Exclusion criteria

Exclusion criteria: Cases with neurological disease, symptomatic cerebral infarction,impossible for performing neuropsychological test, acute phase of infective endocarditis, emergency case and without the evaluation of chest CT and brain MRI.

Design outcomes

Primary

Measure	Time frame
POCD was defined as a 20% score or more reduction in at least two of the neuropsychological test. The evaluation of incident rate of POCD will performed in each different types of cardiovascular surgery	—

Secondary

Measure	Time frame
The association between the development of POCD and patients' background, humoral factors(blood concentration of symmetric dimethylarginine arginine,arginine,eicosapentaenoic acid,docosahexaenoic acid and arachidonic acid),intraoperative monitoring and factors, and postoperative factors will be evaluated.The daily life activity in 1 and 3 month postoperatively will be evaluated by questionnaire.	—

Countries

Japan

Contacts

Public ContactKazuyoshi Ishida

Yamaguchi University Graduate School of Medicine Department of Anesthesiology

ishid002@yamaguchi-u.ac.jp0836-22-2291

Outcome results