erosive GERD
Conditions
Interventions
Every Other Day Administration of Vonoprazan
Every Other Day Administration of Lansoprazole
Sponsors
Department of Gastroenterology, National Hospital Organization Hakodate National Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: erosive GERD patients who receive maintenance therapy with PPI
Exclusion criteria
Exclusion criteria: 1) Receiving P-CAB administration 2) For those PPI maintenance therapy is ineffective 3) Having undergone gastroesophageal surgery 4) In very bad compliance 5) Allergic to PPI or Vonoprazan 6) With serious complications 7) Pregnant, breastfeeding, or possibly pregnant 8) Deemed inappropriate for participation in this study by the principal investigator/sub-investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion of asymptomatic patients. We defined an asymptomatic patient as a patient being free of symptoms according to the symptom diary records for 6 or more days per week | — |
Secondary
| Measure | Time frame |
|---|---|
| suppressive effect of GERD symptoms, proportion of asymptomatic patients at each time point, safety and cost saving effect of P-CAB every other day administration, compliance with every other day administration, proportion of asymptomatic patients at the first month of study drug administration | — |
Countries
Japan
Contacts
Public ContactMamiko Demura
National Hospital Organization Hakodate National Hospital Clinical Research Center
Outcome results
None listed