Randomized double-blind comparative study on the effect of bifidobacteria on the induction of resistance to hen's egg allergy oral immunotherapy

Randomized double-blind comparative study on the effect of bifidobacteria on the induction of resistance to hen's egg allergy oral immunotherapy - Randomized double-blind comparative study on the effect of bifidobacteria on the induction of resistance to hen's egg allergy oral immunotherapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030379

Enrollment

Registered

2018-01-01

Start date

2018-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hen&#39

Interventions

Bifidobacteria, twice a day, 52weeks dexistrin , twice a day, 52weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: a) Obvious hen's egg allergic patients b) Patients who are 5 years or older at the start of the study c) After receiving sufficient explanation for the participation of this study, patients who obtained document consent with the free will of the patient himself or the substitute person with sufficient understanding

Exclusion criteria

Exclusion criteria: a) Of control poor atopic dermatitis or bronchial asthma b) Cardiovascular, Cranial nerve, Renal urology, Hepatobiliary, pancreatic, pancreatic, gastrointestinal, etc, which are serious or have diseases which may affect research c) Implementing other immunotherapy d) Other test responsibilities(shared)Patients judged inappropriate by the doctor as subjects

Design outcomes

Primary

Measure	Time frame
Acquisition rate of egg tolerance at 52 weeks after intervention started	—

Secondary

Measure	Time frame
Egg tolerance acquisition rate at 48 weeks after intervention started Objective indicator (blood: change in eosinophil count, total IgE, antigen specific IgE (egg egg: egg white, egg yolk, ovomucoid), antigen specific IgG4 (egg white, ovomucoid), basophil stimulation test (OVM) , Faeces: intestinal flora, calprotectin, skin,prick test) Side reaction rate on oral immunotherapy Safety assessment (incidence of adverse events)	—

Measure

Time frame

Egg tolerance acquisition rate at 48 weeks after intervention started Objective indicator (blood: change in eosinophil count, total IgE, antigen specific IgE (egg egg: egg white, egg yolk, ovomucoid), antigen specific IgG4 (egg white, ovomucoid), basophil stimulation test (OVM) , Faeces: intestinal flora, calprotectin, skin,prick test) Side reaction rate on oral immunotherapy Safety assessment (incidence of adverse events)

—

Countries

Japan

Contacts

Public ContactTakanori Imai

Showa University Department of Pediatrics

ta-imai@med.showa-u.ac.jp03-3784-8000

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

Randomized double-blind comparative study on the effect of bifidobacteria on the induction of resistance to hen&#39;s egg allergy oral immunotherapy