Establishment of neurocognitive training to improve frontal lobe function in moyamoya disease

Establishment of neurocognitive training to improve frontal lobe function in moyamoya disease - Establishment of neurocognitive training to improve frontal lobe function in moyamoya disease

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030362

Enrollment

Registered

2017-12-12

Start date

2017-12-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

moyamoya disease

Interventions

Neurocognitive training 1 hour/session, 5 sessions/week for 4 weeks, a total of 20 hours

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients between 20 and 65 years of age at the time of consent 2.Those who were diagnosed as moyamoya disease according to the guidelines of MMD proposed by the Research Committee on spontaneous occlusion of the circle of Willis 3.Those patients who gave informed consent based on own will or the will of a guardian

Exclusion criteria

Exclusion criteria: 1.Quasimoyamoya syndrome with conditions such as Down syndrome and neurofibromatosis 2.Stroke with neurological deficit 3.Psychological or neurological disorders which affect the neuropsychological test performance 4.Vision or hearing impairment or motor disability which affects the neuropsychological test performance 5.Contraindications for MRI (cardiac pacemaker, inner ear implant, claustrophobia, etc) 6.Revascularization surgery before the study 7.Conditions in which the principal investigator considers not suitable for participation in the study

Design outcomes

Primary

Measure	Time frame
Percentage of correct answers in the PASAT score before and after the neurocognitive training and the magnitude of change in the scores	—

Secondary

Measure	Time frame
1.Pre- and post-neurocognitive training neuropsychological test results (trail making test part A and B, digit span test, tapping span test, standard verbal paired-associate learning test scores)and the magnitude of change 2.Pre- and post-training morphological and functional imaging results and the magnitude of change 3.Correlation between the morphological and functional imaging results and the neuropsychological performance (the magnitude of change in each score before and after training)	—

Measure

Time frame

1.Pre- and post-neurocognitive training neuropsychological test results (trail making test part A and B, digit span test, tapping span test, standard verbal paired-associate learning test scores)and the magnitude of change 2.Pre- and post-training morphological and functional imaging results and the magnitude of change 3.Correlation between the morphological and functional imaging results and the neuropsychological performance (the magnitude of change in each score before and after training)

—

Countries

Japan

Contacts

Public ContactDaisuke Sawamura

Hokkaido University Graduate School of Biomedical Science and Engineering

dai-sawa@hoku-iryo-u.ac.jp011-706-8183

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026