Randomized Cross-over Trial about immediate effects of manual lymphatic drainage and active supine exercise associated with compression therapy on lower limb lymphedema

Randomized Cross-over Trial about immediate effects of manual lymphatic drainage and active supine exercise associated with compression therapy on lower limb lymphedema - Comparative study of immediate effects of MLD and active supine exercise associated with compression therapy on lower limb lymphedema

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030357

Enrollment

Registered

2017-12-18

Start date

2018-01-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with secondary lower limb lymphedema

Interventions

A:MLD by well-experienced single lymphedema therapist for 30 minutes - Wash out period (1 week) - B: To pedal the ergometer in a supine position with compression therapy for 30 minutes - Wash out peri

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients with secondary lower limb lymphedema(ISL grade at least 2) Possible to perform active exercise Informed consent by her own will

Exclusion criteria

Exclusion criteria: Cellulitis Leakage of lymphatic fluid Deep venous thrombosis and severe Aneurysm Inguinal lymph nodes metastasis Poor general status Fever (greater than 38.0 degrees C) Sever heart disease Pulmonary embolism, acute respiratory failure, sever pulmonary hypertension within the past 3 months Sever hepatic or renal failure Other metabolic disorder (acute thyroiditis etc.) Pacemaker user

Design outcomes

Primary

Measure	Time frame
Evaluation period: Immediate pre-and-post intervention Outcome: Lower limb volume	—

Secondary

Measure	Time frame
Evaluation period: Immediate pre-and-post intervention 1:Pain(Visual Analogue Scale (VAS)) 2:Heaviness(Visual Analogue Scale (VAS)) 3:Pitting or non-pitting 4:Skin stiffness 5:Segmental Water Analysis, Segmental Lean Analysis	—

Countries

Japan

Contacts

Public ContactAsako OKA

Keio University, School of Medicine Department of Rehabilitation Medicine

a-oka@keio.jp03-5363-3833

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026