The preliminary prospective study of Treatment with A thiazide-based diuretic for Nocturnal polYuria associated with hypertensiOn

The preliminary prospective study of Treatment with A thiazide-based diuretic for Nocturnal polYuria associated with hypertensiOn - TANYO study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030330

Enrollment

Registered

2017-12-12

Start date

2018-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nocturnal polyuria

Interventions

Oral administration of trichlormethiazide 2 mg/day for 28 days No treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Nocturnal urinary frequency: twice and more - Nocturnal polyuria index (nocturnal urine volume/24hr urine volume): 0.33 and more - Comorbidity: hypertension

Exclusion criteria

Exclusion criteria: - Administration of diuretics as antihypertensive drugs - Untreated lower urinary tract dysfunction including benign prostatic hyperplasia and overactive bladder - Post-void residual urine: 100 mL and more - Chronic renal disease: G3b and more (eGFR <45 mL/min/1.73m^2) - Chronic heart failure: NYHA Class 3 or 4 - Insomnia associated with mental illness

Design outcomes

Primary

Measure	Time frame
Change in slow wave sleep time after 4 weeks from the start of administration	—

Secondary

Measure	Time frame
Changes after 4 weeks from the start of administration - Nocturnal polyuria index - Nocturnal urinary volume - Diurnal urinary volume - Nocturnal excretoin of sodium in urine - Diurnal excretoin of sodium in urine - Total sleep time - Sleep efficiency - Body fluid	—

Countries

Japan

Contacts

Public ContactTakeshi Inoue

Nara Medical University Department of Urology

you1513tt@yahoo.co.jp0744-22-3051

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026