mild cognitive impairment, Alzheimer'
Conditions
Interventions
Sponsors
National Institute of Radiological Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Subjects with neurodegenerative disease 1.20 years of age or older at the time of obtaining consent. 2.Subjects who can be accompanied by a legal guardian on the day of study participation at the NIRS. 3. Subjects meeting criterias of tauopathy Subjects with traumatic brain injury 1.20 years of age or older at the time of obtaining consent. 2.Subjects who can be accompanied by a legal guardian on the day of study participation at the NIRS. 3.Subjects with ability to make informed consent Healthy volunteers 1.20 years of age or older at the time of obtaining consent. 2.Subjects with ability to make informed consent 2.Subjects who can be accompanied by a legal guardian on the day of study participation at the NIRS. 3.Subjects with ability to make informed consent Healthy volunteers 1.20 years of age or older at the time of obtaining consent. 2.Subjects with ability to make informed consent
Exclusion criteria
Exclusion criteria: 1) Subjects with neurodegenerative disease 1. Subjects with organic brain complications/disorders 2.Subjects with substance-related disorders 3.Subjects with severe physical complications/disorders or a history of such conditions 4. Subjects with claustrophobia 5. Pregnant, possibly pregnant or lactating women 6. From the standpoint of radiation exposure from a nuclear medicine scan, subjects who have participated in other nuclear medicine scans as healthy volunteers in the 6 months prior to the start of this study 7. Subjects who are considered to be inappropriate for participation by doctors with responsibilities in this study 2) Subjects with traumatic brain injury 1. Subjects with any organic brain disorder not due to traumatic brain injury 2. Subjects with severe physical complications/disorders or a history of such conditions 3. Subjects with claustrophobia 4. Pregnant, possibly pregnant or lactating women 5. From the standpoint of radiation exposure from a nuclear medicine scan, subjects who have participated in other nuclear medicine scans as healthy volunteers in the 6 months prior to the start of this study 6. Subjects who are considered to be inappropriate for participation by doctors with responsibilities in this study 3) Healthy volunteers 1. Subjects with organic brain complications/disorders 2. Subjects with substance-related disorders 3.Subjects with severe physical complications/disorders or a history of such conditions 4. Subjects with claustrophobia 5. Pregnant, possibly pregnant or lactating women 6. From the standpoint of radiation exposure from a nuclear medicine scan, subjects who have participated in other nuclear medicine scans as healthy volunteers in the 6 months prior to the start of this study 7. Subjects who are considered to be inappropriate for participation by doctors with responsibilities in this study 8. Subjects with tattoo 9. Subjects with metallic medical device in the body
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| correlation between [18F]PM-PBB3-PET and clinical symptoms | — |
Countries
Japan
Contacts
Public ContactKazuko Suzuki
National Institute of Radiological Sciences Clinical Research Support Section
Outcome results
None listed