Additional postoperative intravenous tranexamic acid administration versus placebo administration for patients treated with intraoperative combined intravenous and intra-articular tranexamic acid in total knee arthroplasty: a randomized, double-blind, placebo-controlled trial

Additional postoperative intravenous tranexamic acid administration versus placebo administration for patients treated with intraoperative combined intravenous and intra-articular tranexamic acid in total knee arthroplasty: a randomized, double-blind, placebo-controlled trial - Additional postoperative intravenous tranexamic acid administration versus placebo in total knee arthroplasty

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030237

Enrollment

100

Registered

2017-12-03

Start date

2018-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee, rheumatoid arthritis, avascular necrosis

Interventions

Additional postoperative intravenous tranexamic acid group: Patients received 1000 mg of tranexamic acid administered intravenously just before skin incision and 1000 mg of tranexamic acid administere

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing unilateral total knee arthroplasty

Exclusion criteria

Exclusion criteria: Known allergic reaction to tranexamic acid

Design outcomes

Primary

Measure	Time frame
The volume of perioperative blood loss measured using the calculated blood volume and change in hemoglobin from preoperative to postoperative day 3	—

Secondary

Measure	Time frame
1. The volume of perioperative blood loss measured using the calculated blood volume and change in hemoglobin from preoperative to postoperative day 7 2. Range of knee motion 3. Complication	—

Countries

Japan

Contacts

Public ContactSachiyuki Tsukada

Hokusuikai Kinen Hospital Orthopaedic Surgery

s8058@nms.ac.jp0293033003

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026