Prospective randomized comparison of effect of dexmedetomidine and remifentanil on intubation, intraoperative hemodynamics and revocery during general anesthesia for laryngeal microsurgery

Prospective randomized comparison of effect of dexmedetomidine and remifentanil on intubation, intraoperative hemodynamics and revocery during general anesthesia for laryngeal microsurgery - Prospective randomized comparison of effect of dexmedetomidine and remifentanil during general anesthesia for laryngeal microsurgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030217

Enrollment

Registered

2017-12-01

Start date

2017-12-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prospective randomized trial

Interventions

Dexmedetomidine diluted with saline 1.0 mcg/kg for 10 minutes loading infusion and saline 5 cc 1 minute bolus before induction of propofol 2 mg/kg and rocuronium 0.5 mg/kg, and then maintenance dose

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ASA 1,2 presenting for laryngeal microsurgery

Exclusion criteria

Exclusion criteria: Refusal to give consent, Hemodynamic instability, Cardiovascular disease, Myocardial infarct, hear frailure, asthma, recent upper respiratory infection, chronic kidney disease, severe liver disease, mental retardation, pregnancy, lactation , antihypertensive medication with angiotensin converting enzyme inhibitor

Design outcomes

Primary

Measure	Time frame
intubation score, and intra-operative hemodynamic stability	—

Secondary

Measure	Time frame
desflurane requirement, emergence time, cough response score, agitation score, sore throat VAS	—

Countries

Asia(except Japan)

Contacts

Public ContactHae Wone Chang

Korea University Guro Hospital Anesthesiology and Pain Medicine

chelenh@gmail.com82226261437

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026