The efficacy and the safety of the DPP4 inhibitor in patients with type 2 diabetes complicated with renal dysfunction

The efficacy and the safety of the DPP4 inhibitor in patients with type 2 diabetes complicated with renal dysfunction - The efficacy and the safety of the DPP4 inhibitor in patients with type 2 diabetes complicated with renal dysfunction

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000030172

Enrollment

400

Registered

2017-11-30

Start date

2018-01-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes mellitus

Interventions

After the dosing for 24 weeks DPP4 inhibitor not requiring capacity adjustment by kidney function, we administer a dose for 24 weeks DPP4 inhibitor requiring capacity adjustment by kidney function.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Type 2 diabetes patients who take DPP4 inhibitor with following 2) or 3). 2)Diabetic nephropathy stage is over II or more. 3)eGFR <60 mL/min/1.73 m2

Exclusion criteria

Exclusion criteria: 1)Contraindicated patient in the attached document of each DPP4 inhibitors 2)Investigator concludes that the patient's participation in this study is inappropriate

Design outcomes

Primary

Measure	Time frame
Change of HbA1c(%), glycoalbumin(%), adverse event, serum creatinine(mg/dL), eGFR(mL/min/1.73m2),urinary protain/creatinine rate(mg/gCre) and urinary albumin/creatinine ratio(mg/gCre) from baseline to end of treatment and the actual self-pay and evaluation of the patient to it at 48week later from an examination start	—

Secondary

Measure	Time frame
Change of BW, liver function at 48week later from an examination start	—

Countries

Japan

Contacts

Public ContactTomohiro Santou

Osaka Saiseikai Noe Hospital Department of Diabetes and Endocrinology

santou@noe.saiseikai.or.jp06-6932-0401

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026