catheter-related blood stream infection
Conditions
Interventions
1) After flush the contents of the catheter with physiological saline, slowly inject 0.1 to 0.7 mL of 70% ethanol into the catheter and lock it for 2 to 4 hours. 2) After locking, firstly aspirate di
Sponsors
The Japanese Society for Metabolism Research in Pediatric Surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Long-term indwelling silicone CVC (Cook, Broviac or Hickman catheter) is placed. 2) Diagnosed as CRBSI. 3) There is consent from the family. 4) Obtained consent from the clinical trial judging committee.
Exclusion criteria
Exclusion criteria: 1) Patients with ethanol allergy 2) Pregnant women, breast milk supplier 3) Patients with hypercoagulability or easy coagulability 4) Patients who can not reverse blood from CVC 5) Patients who can not use ethanol socially, religiously or culturally 6) Patients whose CVC has been detained in another hospital, fewer information including catheter materials, and this method is judged to be maladaptive 7) Patients who have placed PICC or port type CVC 8) Patients who have placed double-lumen CVC and can not lock both lumens at the same time 9) Patients who doctor concluded that it is inappropriate to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Short term assessment of efficacy The definition of successful CVC-ELT required negative blood culture from the lumen of the CVC at day 5 with improvement of blood biochemical examination, disappearance of clinical symptoms such as fever, and no CRBSI relapse within 4 weeks. 2) Evaluation on long-term preservation of CVC Evaluate whether catheter preservation was possible for 4 weeks or more. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of safety a) Presence or absence of skin flushing, drunkenness, nausea etc. during the treatment period b) Presence or absence of liver and kidney dysfunction (BUN, Cr, AST, ALT on day 2.5) | — |
Countries
Japan
Contacts
Public ContactSachiko Miyagawa
Showa University Hospital Division of Pediatric Surgery, Department of Surgery
Outcome results
None listed