Non-small cell lung cancer
Conditions
Interventions
Re-biopsy using the cryoprobe
Sponsors
Kyoto Prefectural University of Medicine Graduate School of Medical Science
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients who confirmed EGFR mutation-positive NSCLC histologically or cytologically and achieved progressive disease on EGFR-TKI treatment who need to access re-biopsy 2. 20 years old or older 3. Informed consent
Exclusion criteria
Exclusion criteria: 1. Poor general condition 2. Lesion located adjacent to the visceral pleura, bulla and large vessel and had high risk of pneumothorax and bleeding on chest CT 3. Lesion located difficult to approach on chest CT 4. Re-examination following prior failure in this trial 5. Patients who need to access non-target lesion by bronchoscopic procedures in the same setting 6. Bleeding tendency 7. Pregnancy 8. Other clinical difficulties in this trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic yield of histology specimens (success rate for re-biopsy) | — |
Secondary
| Measure | Time frame |
|---|---|
| EGFR-T790M detection rate Time required for examination procedure Incidence of adverse effects Tissue areas of biopsies | — |
Countries
Japan
Contacts
Public ContactTatsuya Imabayashi
Kyoto Prefectural University of Medicine Graduate School of Medical Science Department of Pulmonary Medicine
Outcome results
None listed