The association of circulating xanthine oxidase activity and purines with peripheral neuropathy or cognitive functions in type 2 diabetes.

The association of circulating xanthine oxidase activity and purines with peripheral neuropathy or cognitive functions in type 2 diabetes. - The xanthine oxidase activity in type 2 diabetes.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000029970

Enrollment

200

Registered

2017-11-15

Start date

2017-11-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Patients diagnosed with type 2 diabetes 2)Aged over 20. 3)Patients responsible to cognitive functional tests. 4)Having provided voluntary written consent for participation in this study.

Exclusion criteria

Exclusion criteria: 1)Patients with severe complications (liver disease, mental disorder, or cancer). 2)Patients with severe ketosis or diabetic coma. 3)Patients with severe infections, perioperative status, or severe trauma. 4)Patients whose baseline eGFR were <30 ml/min/1.73m^2. 5)Patients treated with uric acid synthesis inhibitor, drugs for dimentia or drugs for neuropathy. 6)Patients who are judged by an investigator to be inappropriate for this study for any other reason.

Design outcomes

Primary

Measure	Time frame
The association of circulationg xanthine oxidase activity and sensetion level with monofilaments or cognitive functions.	—

Countries

Japan

Contacts

Public ContactTomoko Okuyama

Yokohama City University Graduate School of Medicine Department of Endocrinology and Metabolism

oku_tomo@yokohama-cu.ac.jp045-787-2800

Outcome results