Herpetic stromal keratitis
Conditions
Interventions
None listed
Sponsors
Tottori University, Faculty of Medicine Division of Ophthalmology and Visual Science
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients with unilateral and recurred infiltration(s) 2)Patients with corneal hypoesthesia or past history of definitive dendritic keratitis 3)Patients under combined treatment of acyclovir ointment and steroid eye drops 4)more than 20-year-old (at the timing of informed consent agreement) 1), 2), 3) and 4) Tear is collected from normal volunteers as control (just once). Inclusion criteria are as follows. 1)No ophthalmological past history other than refractive error 2)No systemic inflammation 3)more than 20-year-old (at the timing of informed consent agreement)
Exclusion criteria
Exclusion criteria: 1)Patients difficult to be obtained the agreement of participation of this study 2)Patients with high possibility of other causative agents than HSV 3)Patients with catarrhal corneal infiltration 1), 2), or 3)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To quantify HSV-DNA by real-time PCR, and various cytokines by ELISA in tear consecutively after the discontinuation of acyclovir ointment and steroid eye drops in herpetic stromal keratitis patients under treatment, compare with the subsequent incidence of recurrence, and explore the molecule markers of treatment discontinuation. | — |
Secondary
| Measure | Time frame |
|---|---|
| To explore the molecule markers of recurrence prediction by above analyses | — |
Countries
Japan
Contacts
Public ContactYoshitsugu Inoue
Tottori University, Faculty of Medicine Division of Ophthalmology and Visual Science
Outcome results
None listed