Early Detection and Pharmacological Intervention for exercise-induced or cold-pressor-induced PH

Early Detection and Pharmacological Intervention for exercise-induced or cold-pressor-induced PH - Early intervention for exercise-induced or cold-pressor-induced PH

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000029928

Enrollment

Registered

2017-11-10

Start date

2009-07-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

exercise-induced pulmonary hypertension, cold-pressor-induced pulmonary hypertension

Interventions

Pharmacological intervention group. Pulmonary arterial hypertension specific drug (PDE 5 inhibitor and/or endothelin receptor antagonist) shall be orally administered. Non pharmacological intervent

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Male and female adult patients with connective tissue disease who have been diagnosed with Exercise induced pulmonary hypertension. Confirmed diagnosis of exercise induced pulmonary hypertension with: - mPAP < 25 mmHg at rest - mPAP >= 30 mmHg during exercise

Exclusion criteria

Exclusion criteria: -Received pulmonary arterial hypertension specific therapy -History of ischemic heart disease -Severe renal impairment (creatinine clearance <30 ml/min) at Screening -Severe hepatic impairment (Child-Pugh class C with or without cirrhosis) at Screening -Uncontrolled hypertension (>=180/110 mmHg) at Screening -Severe hypotension (<90/50 mmHg) at Screening -active cancer -Females who are pregnant or breastfeeding -Noncompliance with previous medical regimens -Participated in a clinical study involving another investigational drug

Design outcomes

Primary

Measure	Time frame
the change from baseline to year 3 in mean pulmonary arterial pressure at rest	—

Countries

Japan

Contacts

Public ContactYoshito Ogihara

Mie University Graduate School of Medicine Department of Cardiology and Nephrology

yoshito@clin.medic.mie-u.ac.jp059-231-5015

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026