aortic valve stenosis, aortic valve insufficiency, mitral valve stenosis, mitral valve insufficiency
Conditions
Interventions
In landiolol treatment group, patients will be given landiolol intravenously during/after CPB. Landiolol will continuously administrate for 48 hours after begining of CPB.
On the other, in control gro
Sponsors
University of Tsukuba
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)aortic valve stenosis and/or aortic valve insufficiency 2)severity of aortic valve stenosis and/or aortic valve insufficiency are diagnosed as severe grade by preoperative echocardiography. 3)age limtation: 20 =/<, <85 years 4)all participants should obtain written informed consent of this study
Exclusion criteria
Exclusion criteria: 1) emergency surgery 2) shock status before surgery 3) bradycardia (HR<50 bpm), 4) severe AV block 5)additional surgery (CABG, etc) 5) NYHA4 6) The patient who judged a doctor to be inappropriate as a subject
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative af Incidence of arrhythmia after CPB | — |
Secondary
| Measure | Time frame |
|---|---|
| Complication and mortality after surgery hemodynamics during/after surgery duration of hospitalization and ICU stay abnormality of blood chemistry, inflammatory, oxidative stress and ischemic response duration of weaning of CPB | — |
Countries
Japan
Contacts
Public ContactShinji Takahashi
University of Tsukuba Faculty of medicine, department of Anesthesiology
Outcome results
None listed