Birth cohort study to establish pivotal biomarkers that determine oral tolerance or food allergy in infancy

Birth cohort study to establish pivotal biomarkers that determine oral tolerance or food allergy in infancy - Tolerance or Allegy? : Immunoglobulin Affinity Study (TAIGA study)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000029767

Enrollment

150

Registered

2017-10-30

Start date

2017-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Food allergy

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All infants who are born at collaborating maternal hospitals and whose parents give informed consent

Exclusion criteria

Exclusion criteria: Infants who are expected that OFC is not possible at 1 year old by inevitable reasons such as relocation.

Design outcomes

Primary

Measure	Time frame
The relationship between changes in serum levels of food allergen-specific IgE, IgG1, IgG2, IgG3, IgG4, and IgA, antigen affinity of food allergen-specific IgE and IgG1 (measured by highly sensitive DLC/DCP chip assay) in early infancy and oral food challenge outcome (food allergy or tolerance) at 1 year old	—

Secondary

Measure	Time frame
The relationship between other immunological markers and OFC outcome (food allergy or tolerance) at 1 yearold	—

Countries

Japan

Contacts

Public ContactTaiga Kobori

Mie National Hospital Department of Pediatrics

taigar241983@gmail.com059-232-2531

Outcome results