healthy male volunteers
Conditions
Interventions
Positron emission tomography (PET) imaging with [11C]doxepin, a PET tracer that specifically binds to H1Rs, in healthy male volunteers after a single oral administration of placebo in a double-blind c
Sponsors
Department of Pharmacology, Tohoku University Graduate School of Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Healthy normal male subjects examined by health check using blood and brain MRI examination before PET scan
Exclusion criteria
Exclusion criteria: Healthy normal male subjects taking any drugs Healthy normal male subjects who became another volunteers of PET studies. Healthy normal male subjects with severe allergic diseases Healthy normal male subjects with family history of glaucoma and benign prostatic hypertrophy Healthy normal male subjects who can not take antihistamines and anticholinergic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Histamine H1 receptor occupancy of desloratadine 5 mg and loratadine 10 mg at Tmax after single oral administration | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between histamine H1 receptor occupancy and subjective sleepiness and plasma pharmakokinetics after single oral administration of desloratadine 5 mg and loratadine 10 mg. | — |
Countries
Japan
Contacts
Public ContactManabu Tashiro
Tohoku University, Cyclotron and Radioisotope Center Division of Cyclotron Nuclear Medicine
Outcome results
None listed